Life Upside Down made its debut at the 79th Venice Film Festival on September 1, 2021. IFC Films secured the North American distribution rights and launched the film in select theaters and on video on demand on January 27, 2023. It became available for streaming on AMC+ in April 2023. During its opening weekend, the film earned $2,419 across 27 theaters, ultimately accumulating a total of $4,467 in the United States and Canada. Life Upside Down is a flop at Box Office.
